Objective: To study the efficacy of Fu’an Xiaozhen lotions on chronic eczema in mice. Methods: The eczema model was established with dinitrochlorobenzene (DNCB)

and the pruritus model was established with 4-aminopyridine (4-AP)

the mice were divided into the blank group

model group

halmetasone cream group (0.05 g/cm2) and Fu’an Xiaozhen lotions low-concentration

medium-concentration and high-concentration group (0.10 mL/cm2)

and were treated with corresponding countermeasures respectively. The therapeutic effects of Fu’an Xiaozhen lotions on eczema were evaluated by lesion score

ear swelling degree and licking reaction

and the inflammatory changes of skin tissues of mice were observed by hematoxylin-eosin staining. Results: The topical application of Fu’an Xiaozhen lotions can effectively improve the eczema symptoms of mice induced by DNCB

and significantly reduce the inflammatory cell count of mice. There were statistically significant differences between the model group

the medium-concentration and high-concentration Fu’an Xiaozema lotions group in lesion score

licking times and inflammatory cell count (P<0.05). Conclusion: The topical application of Fu’an Xiaozhen lotions has good therapeutic effects on chronic eczema in mice.